What causes granuloma annulare? Why do other types of granulomas appear? Can you do anything about them? Discover now!

The types of granulomas are different in the human body, as they respond to an incomplete immune reaction. They can be be due to an infection that does not resolve or by a foreign body that is surrounded to try to eliminate it. Find out more in the article.

There are various types of granulomas that manifest as a response of the body to an aggressive agent that cannot be resolved in the usual way. That is, we are facing an injury that denotes the inability of the defense cells to carry out an adequate elimination.

By definition, a granuloma is an accumulation of cells in the form of a tumor around something that is identified as foreign to the body. The cells in question belong to the immune system and the foreign agent can be a microorganism or an inert particle.

The above is what will determine the different clinical pictures, although similar if seen under a microscope. To learn more about it, below we detail the characteristics of each one.

Types of granulomas

Once a granuloma has started, the types that can become present depend on what you are trying to remove. At the same time, the varieties differ in the product of the response and in the possibility of being in one area or expanding to more tissues in an uncontrollably.

Pyogenic granuloma

One of the types of granulomas is pyogenic. Although there are no specific causes, it is associated with microorganisms that enter under the skin through small wounds, and that are encapsulated by the immune system without completely eliminating it to the outside.

The process takes time, since the injury occurs first and, later, the granulomatous reaction. The most frequent sites of appearance are the upper extremities and the face. This is to be the case due to the higher frequency of superficial wounds that usually occur in these anatomical areas.

The clinical form is a lump, like a benign tumor. They tend to have repetitive bleeding that occurs by rubbing, scratching or spontaneously. Their red color is due to the number of small blood vessels they have.

Many granulomas go away without treatment. The explanation would be that the body, finally, manages to resolve the expulsion of the foreign body present. In other cases, it is necessary to intervene, either with incisions or laser surgery to remove them.

What causes granuloma annulare and its types?

As the name implies, these types of granulomas have a characteristic ring-shaped lesion. The skin protrudes in reddish circles, especially on the hands and feet.

The most common form is localized. In these cases, there are injurious rings, of about 5 centimeters, which are concentrated in specific anatomical regions, without expanding to the rest of the body.

The cause is not familiar yet, although we know about hte risk factors that favor its appearance. Diabetic patients, for example, are more susceptible. Cancer people are also affected by a repetitive variety of granuloma annulare that is difficult to treat.

Symptoms are mild, painless. Sometimes there is an almost imperceptible itch. As in pyogenic granuloma, the evolution can lead to spontaneous resolution or require an interventional approach.

Generalized granuloma annulare

The generalized form of granuloma annulare differs from the previous one in the expansion that occurs between anatomical areas of the body. The lesions are in the shape of a ring, reddish, with slight itching, over most of the skin.

It spontaneously resolve, but it usually takes 2 years to complete the entire cycle from its appearance. Its priority population is adult women, especially those over 40 years of age. It does not become malignant, despite its extent. Nor can it be linked to a specific infection.

The most effective treatment is with a combination of antibiotics. The most widely used regimen uses rifampicin, ofloxacin, and minocycline. Sometimes doctors prescribe corticosteroids and even immunomodulators to help.

Perforating granuloma annulare

As another type of granuloma, a variety of the previous annular ones, we have the perforator. Insect bites, UV exposure, hormonal imbalances from insulin, and hypothyroidism have been speculated on.

It can be accompanied by vasculitis near the dermal lesions. This is an inflammation of the blood vessels that break more easily, heal poorly and with representation in subcutaneous hemorrhages such as punctate or petechiae.

The characteristic sign of the perforating granuloma is its navel appearance. In the center of the ring of injury there is usually a collapse of the tissue with a viscous substance. This fluid is collagen that seeps from under the skin to the surface. They can be on the hands, abdomen, and back.

The treatment is not so consensual due to the unusual nature of the pathology. Corticosteroids tend to combine with antihistamines, as well as immunomodulators. You can take the drugs orally or locally (creams). If necessary, doctors can apply laser or phototherapy.

The diagnosis of each type of granuloma is the beginning

This pathology requires proper treatment, but more importantly, an accurate diagnosis. The types of granulomas require the intervening dermatologist to have an acute capacity for analysis and interpretation of biopsies.

It will always be preferable that a health professional weighs the alternatives and offers the most appropriate for the case.

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